ساخت و مشخصه‌یابی نانوکامپوزیت اکسید گرافن کاهش یافته-‌اکسید روی و بررسی قابلیت آن برای کاربردهای پزشکی

نوع مقاله: مقاله پژوهشی کامل

نویسندگان

1 دانشگاه پیام نور مشهد

2 مجتمع آموزش عالی فنی و مهندسی اسفراین

3 دانشگاه علوم پزشکی مشهد

چکیده

نانوکامپوزیت اکسید گرافن کاهش یافته-اکسید روی (72/0، 36/0، 18/0= (GO/Zn(Ac) با استفاده از اکسید گرافن و استات روی به‌روش حمام شیمیایی تهیه شد. مشخصه‌یابی‌ اپتیکی، با استفاده از آنالیزهای DRS، FTIR و مشخصه‌یابی ساختاری، توسط آنالیزهای XRD، SEM و EDS صورت گرفت. طیف DRS نانوکامپوزیت  RGO-ZnOلبه جذبی را در nm 386 نشان داد. در طیف FTIR قلة جذب مربوط به پیوند ZnO و همچنین کاهش اکسید گرافن به‌خوبی دیده شد و همچنین قله‌های ایجاد شده در الگوی XRD تشکیل ساختار هگزاگونال ZnO را تأیید کرد. تصاویر SEM نشان داد که ذرات ZnO روی صفحات گرافن قرار گرفته‌اند. وجود روی در نانوکامپوزیت  RGO-ZnOتوسط قله‌های Zn در داده‌های EDS ثابت شد. در نهایت، اثر سمیت (ضد سرطانی) اکسید گرافن و سه نمونه با درصد مختلف ZnO از نانوکامپوزیت بر روی درصد حیات سلول‌های رده نوروبلاستوما (N2A) بررسی شد. نتایج نشان داد که نمونه GO و نانوکامپوزیت‌های  RGO-ZnOبا نسبت GO/Zn(Ac) برای 18/0 و 36/0 دارای اثرات سمیت مشابه‌ای بر روی بقای سلول‌های N2A هستند و در غلظت‌های بالا سبب سمیت بیشتری بر روی این سلول‌ها شدند. اما در مورد نانوکامپوزیت RGO-ZnO با نسبت 72/0 = GO/Zn(Ac) این اثر سمیت در غلظت‌های پایین‌تر مشاهده شد.

کلیدواژه‌ها


عنوان مقاله [English]

Synthesis and characterization of rGO-ZnO nanocomposites and investigating their potential for medical applications

نویسنده [English]

  • Ali Khorsand Zak 2
چکیده [English]

Reduced graphene oxide-ZnO (72/0، 36/0، 18/0= GO/Zn(Ac)) was synthesized using GO and Zn(Ac) by a chemical bath root. The optical properties were performed by FTIR and DRS spectroscopies and the structural properties by XRD, SEM and EDS observations. The DRS spectra of rGO-ZnO show an absorption edge at about 389 nm. The vibration modes related to ZnO bonds and also reduction of GO were observed by FTIR spectra. The XRD, EDS and SEM results showed that ZnO was formed in a hexagonal structure on the rGO surfaces. The toxicity of the prepared samples was studied on (N2A) cellulose. It was shown that GO and rGO-ZnO with 0.18 and 0.36 GO/Zn(Ac) ratio have similar toxicity behaviors in higher concentration compared to the 0.72 which shows toxicity in lower concentrations.   

کلیدواژه‌ها [English]

  • Graphene
  • Graphene oxide
  • Nanocomposite
  • Zinc oxide
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