ساخت و مشخصه‌یابی نانوکامپوزیت اکسید گرافن کاهش یافته-‌اکسید روی و بررسی قابلیت آن برای کاربردهای پزشکی

نوع مقاله : مقاله پژوهشی کامل

نویسندگان

1 دانشگاه پیام نور مشهد

2 مجتمع آموزش عالی فنی و مهندسی اسفراین

3 دانشگاه علوم پزشکی مشهد

چکیده

نانوکامپوزیت اکسید گرافن کاهش یافته-اکسید روی (72/0، 36/0، 18/0= (GO/Zn(Ac) با استفاده از اکسید گرافن و استات روی به‌روش حمام شیمیایی تهیه شد. مشخصه‌یابی‌ اپتیکی، با استفاده از آنالیزهای DRS، FTIR و مشخصه‌یابی ساختاری، توسط آنالیزهای XRD، SEM و EDS صورت گرفت. طیف DRS نانوکامپوزیت  RGO-ZnOلبه جذبی را در nm 386 نشان داد. در طیف FTIR قلة جذب مربوط به پیوند ZnO و همچنین کاهش اکسید گرافن به‌خوبی دیده شد و همچنین قله‌های ایجاد شده در الگوی XRD تشکیل ساختار هگزاگونال ZnO را تأیید کرد. تصاویر SEM نشان داد که ذرات ZnO روی صفحات گرافن قرار گرفته‌اند. وجود روی در نانوکامپوزیت  RGO-ZnOتوسط قله‌های Zn در داده‌های EDS ثابت شد. در نهایت، اثر سمیت (ضد سرطانی) اکسید گرافن و سه نمونه با درصد مختلف ZnO از نانوکامپوزیت بر روی درصد حیات سلول‌های رده نوروبلاستوما (N2A) بررسی شد. نتایج نشان داد که نمونه GO و نانوکامپوزیت‌های  RGO-ZnOبا نسبت GO/Zn(Ac) برای 18/0 و 36/0 دارای اثرات سمیت مشابه‌ای بر روی بقای سلول‌های N2A هستند و در غلظت‌های بالا سبب سمیت بیشتری بر روی این سلول‌ها شدند. اما در مورد نانوکامپوزیت RGO-ZnO با نسبت 72/0 = GO/Zn(Ac) این اثر سمیت در غلظت‌های پایین‌تر مشاهده شد.

کلیدواژه‌ها


عنوان مقاله [English]

Synthesis and characterization of rGO-ZnO nanocomposites and investigating their potential for medical applications

نویسنده [English]

  • Ali Khorsand Zak 2
چکیده [English]

Reduced graphene oxide-ZnO (72/0، 36/0، 18/0= GO/Zn(Ac)) was synthesized using GO and Zn(Ac) by a chemical bath root. The optical properties were performed by FTIR and DRS spectroscopies and the structural properties by XRD, SEM and EDS observations. The DRS spectra of rGO-ZnO show an absorption edge at about 389 nm. The vibration modes related to ZnO bonds and also reduction of GO were observed by FTIR spectra. The XRD, EDS and SEM results showed that ZnO was formed in a hexagonal structure on the rGO surfaces. The toxicity of the prepared samples was studied on (N2A) cellulose. It was shown that GO and rGO-ZnO with 0.18 and 0.36 GO/Zn(Ac) ratio have similar toxicity behaviors in higher concentration compared to the 0.72 which shows toxicity in lower concentrations.   

کلیدواژه‌ها [English]

  • Graphene
  • Graphene oxide
  • Nanocomposite
  • Zinc oxide
[1]                W. Choi, J.-w. Lee, Graphene: synthesis and applications, CRC Press (2011).
[2]                W. Du, X. Jiang, L. Zhu, From graphite to graphene: direct liquid-phase exfoliation of graphite to produce single- and few-layered pristine graphene, Journal of Materials Chemistry A 1 (2013) 10592.
[3]                G. Liu, W. Jin, N. Xu, Graphene-based membranes, Chemical Society reviews, 44 (2015) 5016-5030.
[4]                Y. Wang, Z. Li, J. Wang, J. Li, Y. Lin, Graphene and graphene oxide: biofunctionalization and applications in biotechnology, Trends in biotechnology, 29 (2011) 205-212.
[5] س.س. توسلمند، م. هاشمی، طراحی فرامواد گرافینی با قابلیت تنظیم خواص اپتیکی، پژوهش سیستم‌های بس‌ذره‌ای، 6 (2016) 127-134.
[6] R. Heyrovska, Atomic structures of graphene, benzene and methane with bond lengths as sums of the single, double and resonance bond radii of carbon, arXiv preprint arXiv 0804.4086 (2008).
]7[ K.S. Novoselov, A.K. Geim, S. Morozov, D. Jiang, Y. Zhang, S.a. Dubonos, I. Grigorieva, A. Firsov, Electric field effect in atomically thin carbon films, science, Science 306 (2004) 666-669.
[8[ C.K. Chua, M. Pumera, Chemical reduction of graphene oxide: a synthetic chemistry viewpoint, Chemical Society reviews 43 (2014) 291-312.
[9] W. Jie, J. Hao, Graphene-based hybrid structures combined with functional materials of ferroelectrics and semiconductors, Nanoscale 6 (2014) 6346-6362.
[10] K.S. Mali, J. Greenwood, J. Adisoejoso, R. Phillipson, S. De Feyter, Nanostructuring graphene for controlled and reproducible functionalization, Nanoscale 7 (2015) 1566-1585.
[11] J. Wei, T. Vo, F. Inam, Epoxy/graphene nanocomposites – processing and properties: a review, RSC Adv. 5 (2015) 73510-73524.
[12] E.L. Wolf, Applications of Graphene: An Overview, Springer (2014).
]13[ G. Zhao, T. Wen, C. Chen, X. Wang, Synthesis of graphene-based nanomaterials and their application in energy-related and environmental-related areas, RSC Advances 2 (2012) 9286.
]14[V. Skákalová, A.B. Kaiser, Graphene: properties, preparation, characterisation and devices, Elsevier (2014).
[15] X. Zhou, T. Shi, H. Zhou, Hydrothermal preparation of ZnO-reduced graphene oxide hybrid with high performance in photocatalytic degradation, Applied Surface Science 258 (2012) 6204-6211.
[16] J. Zhao, L. Liu, F. Li, Graphene oxide: Physics and applications, Springer (2015).
[17] B. Bhushan, D. Luo, S.R. Schricker, W. Sigmund, S. Zauscher, Handbook of nanomaterials properties, Springer Science & Business Media (2014).
[18] R. Sharma, F. Alam, A.K. Sharma, V. Dutta, S.K. Dhawan, ZnO anchored graphene hydrophobic nanocomposite-based bulk heterojunction solar cells showing enhanced short-circuit current, Journal of Materials Chemistry C 2 (2014) 8142-8151.
[19] Z.C. Feng, Handbook of Zinc Oxide and Related Materials: Volume Two, Devices and Nano-Engineering, CRC Press (2012).
[20] M.K. Kavitha, S.C. Pillai, P. Gopinath, H. John, Hydrothermal synthesis of ZnO decorated reduced graphene oxide: Understanding the mechanism of photocatalysis, Journal of Environmental Chemical Engineering 3 (2015) 1194-1199.
[21] J. He, C. Niu, C. Yang, J. Wang, X. Su, Reduced graphene oxide anchored with zinc oxide nanoparticles with enhanced photocatalytic activity and gas sensing properties, RSC Advances 4 (2014) 60253-60259.
[22] Y.W. Wang, A. Cao, Y. Jiang, X. Zhang, J.H. Liu, Y. Liu, H. Wang, Superior antibacterial activity of zinc oxide/graphene oxide composites originating from high zinc concentration localized around bacteria, ACS applied materials & interfaces 6 (2014) 2791-2798.
[23] G. Eda, Y.Y. Lin, C. Mattevi, H. Yamaguchi, H.A. Chen, I.S. Chen, C.W. Chen, M. Chhowalla, Blue photoluminescence from chemically derived graphene oxide, Advanced materials 22 (2010) 505-509.
[24] S.K. Singh, M.K. Singh, P.P. Kulkarni, V.K. Sonkar, J.J. Gracio, D. Dash, Amine-modified graphene: thrombo-protective safer alternative to graphene oxide for biomedical applications, ACS nano 6 (2012) 2731-2740.
[25] C. Bosch-Navarro, E. Coronado, C. Marti-Gastaldo, J.F. Sanchez-Royo, M.G. Gomez, Influence of the pH on the synthesis of reduced graphene oxide under hydrothermal conditions, Nanoscale 4 (2012) 3977-3982.
[26] C. Gao, X.Y. Yu, R.X. Xu, J.H. Liu, X.J. Huang, AlOOH-reduced graphene oxide nanocomposites: one-pot hydrothermal synthesis and their enhanced electrochemical activity for heavy metal ions, ACS applied materials & interfaces 4 (2012) 4672-4682.
[27] C. Nethravathi, M. Rajamathi, Chemically modified graphene sheets produced by the solvothermal reduction of colloidal dispersions of graphite oxide, Carbon 46 (2008) 1994-1988.
[28] Y. Feng, N. Feng, Y. Wei, G. Zhang, An in situ gelatin-assisted hydrothermal synthesis of ZnO–reduced graphene oxide composites with enhanced photocatalytic performance under ultraviolet and visible light, RSC Advances, 4, (2014) 7933-7943.
 [29] X. Li, Q. Wang, Y. Zhao, W. Wu, J. Chen, H. Meng, Green synthesis and photo-catalytic performances for ZnO-reduced graphene oxide nanocomposites, Journal of colloid and interface science, 411 (2013) 69-75.
[30] M. Nasrollahzadeh, B. Jaleh, A. Jabbari, Synthesis, characterization and catalytic activity of graphene oxide/ZnO nanocomposites, RSC Advance 4 (2014) 36713.
[31] K. Babitha, J.J. Matilda, A.P. Mohamed, S. Ananthakumar, Catalytically engineered reduced graphene oxide/ZnO hybrid nanocomposites for the adsorption, photoactivity and selective oil pick-up from aqueous media, RSC Advances 5 (2015) 50223-50233.
[32] F. Ban, S.R. Majid, N.M. Huang, H.N. Lim, Graphene oxide and its electrochemical performance, International Journal of Electrochemical Science 7 (2012) 4345-4351.
[33] M.K. Kavitha, H. John, P. Gopinath, R. Philip, Synthesis of reduced graphene oxide–ZnO hybrid with enhanced optical limiting properties, Journal of Materials Chemistry C 1 (2013) 3669.
[34] F. Wu, Y. Xia, Y. Wang, M. Wang, Two-step reduction of self-assembed three-dimensional (3D) reduced graphene oxide (RGO)/zinc oxide (ZnO) nanocomposites for electromagnetic absorption, Journal of Materials Chemistry A 2 (2014) 20307-20315.
[35] S. Gayathri, P. Jayabal, M. Kottaisamy, V. Ramakrishnan, Synthesis of ZnO decorated graphene nanocomposite for enhanced photocatalytic properties, Journal of Applied Physics, 115 (2014) 173504.
[36] Z.-J. Fan, W. Kai, J. Yan, T. Wei, L.-J. Zhi, J. Feng, Y.-m. Ren, L.-P. Song, F. Wei, Facile synthesis of graphene nanosheets via Fe reduction of exfoliated graphite oxide, ACS nano 5 (2010) 191-198.