ساخت نانوذرات ZnS:Mn و بررسی توانایی تولید گونه‌های فعال اکسیژن توسط آن‌ها

نوع مقاله: مقاله پژوهشی کامل

نویسندگان

1 دانشگاه کاشان

2 رئیس دانشکده فیزیک

چکیده

امروزه نانوذرات نیمه‌هادی، توجه بسیاری را در شاخه‌های نانو پزشکی به خود جلب کرده‌اند. در این تحقیق توانایی نانوذرات ZnS:Mn در تولید گونه‌های فعال اکسیژن شامل رادیکال هیدروکسیل بررسی شد و همچنین روش سنتز نانوذرات ZnS:Mn گزارش شد. نانوذرات ZnS:Mn به روش هم‌رسوبی ساخته شد. تحریک نانوذرات توسط پرتو UV انجام گرفت. مشخصه‌یابی ساختار نانوذرات تهیه شده با استفاده از آنالیزهای XRD, TEM، SEM و PL انجام گرفت. طیف نشر نانوذرات ZnS:Mn دارای 2 قله مشخص در طول موج‌های 444 و 587 نانومتر است. اندازه نانوذرات تولید شده با استفاده از طیف XRD حدود 24 نانومتر بدست آمد که این با تصاویر SEM و TEM بدست آمده در توافق است. با توجه به کاهش شدت جذب شناساگر متیلن بلو در پرتودهی به همراه نانوذرات ساخته شده نسبت به حالت بدون پرتودهی، می‌توان گفت که نانوذرات ZnS:Mn قادر به ایجاد رادیکال هیدروکسیل می‌باشند. این امر نشان‌دهنده امکان استفاده از این نانوذرات در درمان سرطان به روشی مانند فوتوداینامیک می‌باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Synthesis of ZnS:Mn Nanoparticles And Investigaton of Its Ability to Produce Reactive Oxygen Species

نویسندگان [English]

  • ehsan sadeghi 1
  • mostafa zahedifar 2
  • zahra mahmoodian 1
1 university of kashan
چکیده [English]

Today, semiconductor nanoparticles have attracted much attention in nano-medicine branches. In this study, the ability of the ZnS:Mn nanoparticles to produce reactive oxygen species including radical hydroxyl were investigated and also preparation method of these nanoparticles was reported. ZnS:Mn nanoparticles were synthesized using co-precipitation method. Excitation of nanoparticles was done by UV radiation. The formation and structure of nanostructures was investigated by XRD, SEM and PL analysis. The PL emission spectrum of the ZnS:Mn nanoparticles shows two main peaks in wavelength of 444 and 587 nm. The size of ZnS:Mn nanoparticles was obtained at about 24 nm using XRD result which it is in agreement to SEM and TEM images. According to the decrease in absorption intensity of methylene blue detector in irradiation alongside prepared nanoparticles, it can be said that ZnS:Mn nanoparticles are able to create hydroxyl radicals. This suggests that ZnS:Mn nanoparticles can be used to cancer therapy in photodynamic therapy method.

کلیدواژه‌ها [English]

  • ZnS:Mn nanoparticles
  • absorption spectrum
  • Methylene blue
  • Hydroxyl radical
  • PL
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