طراحی آشکارساز زیستی بر مبنای کروموزوم انسانی

بهنیا, سهراب; فتحی زاده, سمیرا; نعمتی ریشکان, فاطمه

doi:10.22055/jrmbs.2024.19513

طراحی آشکارساز زیستی بر مبنای کروموزوم انسانی

نوع مقاله : مقاله پژوهشی کامل

نویسندگان

گروه فیزیک، دانشکده علوم فناوری‌های نوین، دانشگاه صنعتی ارومیه، ارومیه، ایران

10.22055/jrmbs.2024.19513

چکیده

ما حسگرهای زیستی را بر اساس کروموزوم انسانی (توالی CH22) بررسی کردیم. نتایج نشان می‌دهد که انتقال الکترونیکی و اسپینی توالی CH22 به‌شدت به فرکانس و دامنة نور فرودی و تنش مکانیکی وابسته است. بر این اساس، در محدودة فرکانس مشخص شده از 4 به 5 تراهرتز (THz)، این سیستم قابلیت CH22 را برای انتقال حداکثر جریان الکتریکی نشان می‌دهد. علاوه بر این، با اعمال تنش طولی که با 4 نشان داده می‌شود، مشاهده می‌گردد که سیستم انتقال حداکثر جریان اسپین را تسهیل می‌کند. علاوه بر این، این مطالعة ظهور ناحیه‌ای با مقاومت دیفرانسیل منفی را در پاسخ به تغییرات ولتاژ بایاس نشان می‌دهد، پدیده‌ای که در غیاب نور فرودی و شیب DNA، حتی زمانی که تنش مکانیکی اعمال می‌شود، رخ نمی‌دهد. همچنین نتایج نشان داد که تنش مکانیکی مثبت نسبت به تنش منفی تأثیر بهتری بر تشکیل جریان اسپین دارد. ابزارهای تشخیص پزشکی مبتنی بر پلاریزاسیون اسپین جایگاه ویژه‌ای در پزشکی دارند. این حسگرها با کنترل دقیق پارامترهای مؤثر بر حمل و نقل الکتریکی و اسپین می‌توانند تغییرات بیومولکولی را با حساسیت بالا در محیط‌های بیولوژیکی تشخیص دهند که می‌تواند تغییر اساسی در طراحی سیستم‌های نظارت پزشکی مدرن ایجاد کند.

کلیدواژه‌ها

موضوعات

شاخه‌های میان‌رشته‌ای

عنوان مقاله [English]

Design of biological detector based on human chromosome

نویسندگان [English]

Sohrab Behnia
Samira Fathizadeh
Fatemeh Nemati Rishakan

Faculty member, Faculty of physics,Urmia university of Technology

چکیده [English]

This study investigated biosensors based on the human chromosome (CH22 sequence. The results showed that the electronic and spin transfer of the CH22 sequence is strongly dependent on the frequency and amplitude of incident light and mechanical stress. Accordingly, within the specified frequency domain of 4 to 5 terahertz (THz), the system demonstrates the CH22 capability to transfer the maximum electric current. Furthermore, upon the application of longitudinal stress quantified strain which is denoted by (S₁=4), it is observed that the system facilitates the transmission of the maximal spin current. Furthermore, this study showed the emergence of a region of negative differential resistance in response to bias voltage changes, a phenomenon that does not occur in the absence of incident light and DNA tilt, even when mechanical stress is applied. Also, the results showed that positive mechanical stress has a better effect on the formation of spin flow than negative stress. Medical diagnostic tools based on spin polarization have a special place in medicine. By accurately controlling the parameters affecting electrical and spin transport, these sensors can detect biomolecular changes with high sensitivity in biological environments, which can create a fundamental change in the design of modern medical monitoring systems.

کلیدواژه‌ها [English]

Biological materials
Biological detector
Optoelectronics
Spintronics
Piezospintronics

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