Design of biological detector based on human chromosome

Document Type : Full length research Paper

Authors

1 Faculty member, Faculty of physics,Urmia university of Technology

2 Faculty member, Urmia university of technology

3 Faculty of physics, Urmia university of technology

Abstract

This study investigated biosensors based on the human chromosome (CH22 sequence. The results showed that the electronic and spin transfer of the CH22 sequence is strongly dependent on the frequency and amplitude of incident light and mechanical stress. Accordingly, within the specified frequency domain of 4 to 5 terahertz (THz), the system demonstrates the CH22 capability to transfer the maximum electric current. Furthermore, upon the application of longitudinal stress quantified strain which is denoted by (S1=4), it is observed that the system facilitates the transmission of the maximal spin current. Furthermore, this study showed the emergence of a region of negative differential resistance in response to bias voltage changes, a phenomenon that does not occur in the absence of incident light and DNA tilt, even when mechanical stress is applied. Also, the results showed that positive mechanical stress has a better effect on the formation of spin flow than negative stress. Medical diagnostic tools based on spin polarization have a special place in medicine. By accurately controlling the parameters affecting electrical and spin transport, these sensors can detect biomolecular changes with high sensitivity in biological environments, which can create a fundamental change in the design of modern medical monitoring systems.

Keywords

Main Subjects

References

[1] I. Žutić, J. Fabian, S.D. Sarma, Spintronics: Fundamentals and applications, Reviews of modern physics, 76 (2004) 323.  https://doi.org/14.1143/RevModPhys.76.323
[2] S. Fathizadeh, S. Behnia, J. Ziaei, Engineering DNA molecule bridge between metal electrodes for high-performance molecular transistor: an environmental dependent approach, The Journal of Physical Chemistry B, 122 (2018) 2487-2494. https://doi.org/10.1021/acs.jpcb.7b10034
[3] P.C. Mondal, W. Mtangi, C. Fontanesi, Chiro‐Spintronics: Spin‐Dependent Electrochemistry and Water Splitting Using Chiral Molecular Films, Small methods, 2 (2018) 1700313. https://doi.org/10.1002/smtd.201700313
[4] H. Wang, F. Yin, L. Li, M. Li, Z. Fang, C. Sun, B. Li, J. Shi, J. Li, L. Wang, Twisted DNA origami-based chiral monolayers for spin filtering, Journal of the American Chemical Society, (2024). https://doi.org/10.1021/jacs.3c11566
[5] B. Mikaeeli Kangarshahi, S.M. Naghib, N. Rabiee, DNA/RNA-based electrochemical nanobiosensors for early detection of cancers, Critical reviews in clinical laboratory sciences, (2024) 1-23. https://doi.org/10.1080/10408363.2024.2321202
[6] H. Qi, L. Wang, K.-w. Wong, Z. Du, DNA-quantum dot sensing platform with combined Förster resonance energy transfer and photovoltaic effect, Applied Physics Letters, 94 (2009). https://doi.org/10.1063/1.3117193
[7] M. Minunni, S. Tombelli, M. Mascini, A. Bilia, M.C. Bergonzi, F.F. Vincieri, An optical DNA-based biosensor for the analysis of bioactive constituents with application in drug and herbal drug screening, Talanta, 65 (2005) 578-585. https://doi.org/10.1016/j.talanta.2004.07.020
[8] R. Kobun, Nanotechnology-based optical biosensors for food applications, Adv Food Anal Tools, (2021) 147-165. https://doi.org/10.1016/B978-0-12-820591-4.00008-6
[9] S. Shi, X. Wang, W. Sun, X. Wang, T. Yao, L. Ji, Label-free fluorescent DNA biosensors based on metallointercalators and nanomaterials, Methods, 64 (2013) 305-314. https://doi.org/10.1016/j.ymeth.2013.07.004
[10] J. Li, G. Speyer, O.F. Sankey, Conduction switching of photochromic molecules, Physical review letters, 93 (2004) 248302. https://doi.org/10.1103/PhysRevLett.93.248302
[11] H. Wang, H.K. Bisoyi, A.M. Urbas, T.J. Bunning, Q. Li, Reversible circularly polarized reflection in a self-organized helical superstructure enabled by a visible-light-driven axially chiral molecular switch, Journal of the American Chemical Society, 141 (2019) 8078-8082. https://doi.org/10.1021/jacs.9b03231
[12] S. Behnia, F. Nemati, S. Fathizadeh, Modulation of spin transport in DNA-based nanodevices by temperature gradient: A spin caloritronics approach, Chaos, Solitons & Fractals, 116 (2018) 8-13. https://doi.org/14.1416/j.chaos.2410.49.446
[13] I. Likhachev, V. Lakhno, The direct investigation of DNA denaturation in Peyrard-Bishop-Dauxois model by molecular dynamics method, Chemical Physics Letters, 727 (2019) 55-58. https://doi.org/10.1016/j.cplett.2019.04.027
[14] A. Travers, G. Muskhelishvili, DNA structure and function, The FEBS journal, 282 (2015) 2279-2295. https://doi.org/10.1111/febs.13307
[15] S. Mohammadi, M. Esmailpour, F. Khoeini, Investigation of Graphene and Silicene-DNA nanostructures: DNA Sensing, Journal of Research on Many-body Systems, 10(202) 1-12. https://doi.org/10.22055/jrmbs.2020.15567
[16] T. Dauxois, M. Peyrard, A.R. Bishop, Entropy-driven DNA denaturation, Physical Review E, 47 (1993) R44. https://doi.org/10.1103/PhysRevE.47.R44.
[17] J. Yi, Conduction of DNA molecules: A charge-ladder model, Physical Review B, 68 (2003) 193103. https://doi.org/10.1103/PhysRevB.68.193103 
[18] S. Behnia, S. Fathizadeh, J. Ziaei, Controlling charge current through a DNA based molecular transistor, Physics Letters A, 381 (2017) 36-43. https://doi.org/10.1016/j.physleta.2016.10.037 
[19] S. Fathizadeh, S. Behnia, F. Nemati, M. Salimi, H. Borjkhani, Chaotic control of the dynamical behavior of covid-19 through the electromagnetic fields, Physica Scripta, 97 (2022) 085008. https://doi.org/10.1088/1402-4896/ac7fc1
[20] Y.S. Joe, S. Malakooti, E.R. Hedin, Controllable negative differential resistance on charge transport through strained and tilted DNA molecules, International Journal of Modern Physics B, 33 (2019) 1950099. https://doi.org/14.1142/S4217979219544991
[21] X. Yang, Q. Wang, K. Wang, W. Tan, J. Yao, H. Li, Electrical switching of DNA monolayers investigated by surface plasmon resonance, Langmuir, 22 (2006) 5654-5659. https://doi.org/10.1021/la052907m
[22] U. Rant, K. Arinaga, S. Fujita, N. Yokoyama, G. Abstreiter, M. Tornow, Dynamic electrical switching of DNA layers on a metal surface, Nano Letters, 4 (2004) 2441-2445. https://doi.org/10.1021/nl0484494
[23] C.-J. Xia, D.-S. Liu, H.-C. Liu, X.-J. Zhai, Large negative differential resistance in a molecular device with asymmetric contact geometries: a first-principles study, Physica E: Low-dimensional Systems and Nanostructures, 43 (2011) 1518-1521. https://doi.org/10.1016/j.physe.2011.04.020
[24] S. Behnia, S. Fathizadeh, A. Akhshani, DNA spintronics: Charge and spin dynamics in DNA wires, The Journal of Physical Chemistry C, 120 (2016) 2973-2983. https://doi.org/10.1021/acs.jpcc.5b09907
[25] S. Lakshmi, S. Dutta, S.K. Pati, Molecular electronics: effect of external electric field, The Journal of Physical Chemistry C, 112 (2008) 14718-14730. https://doi.org/10.1021/jp800187e
[26] M. Filianina, Z. Wang, L. Baldrati, K. Lee, M. Vafaee, G. Jakob, M. Kläui, Impact of the interplay of piezoelectric strain and current-induced heating on the field-like spin–orbit torque in perpendicularly magnetized Ta/Co20Fe60B20/Ta/MgO film, Applied Physics Letters, 118 (2021). https://doi.org/10.1063/5.0035869
[27] S. Kuzmin, W. Duley, Properties of specific electron helical states leads to spin filtering effect in dsDNA molecules, Physics Letters A, 378 (2014) 1647-1650. https://doi.org/10.1016/j.physleta.2014.04.019
Journal of Research on Many-body Systems
Volume 14, Issue 2 - Serial Number 41
2024 summer
August 2024
Pages 15-26

Files

History

  • Receive Date: 07 December 2022
  • Revise Date: 09 June 2024
  • Accept Date: 23 September 2024

Share

How to cite

Statistics